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Antimicrobial Drugs and Community-acquired Clostridium difficile?associated Disease, UK

In a population-based case-control study of community-acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months.

Emerg Infect Dis [serial on the Internet]. Volume 13, Number 5-May 2007 J.A. Chris Delaney, Sandra Dial, Alan Barkun, and Samy Suissa McGill University Health Center, Montreal, Quebec, Canada Available from http://www.cdc.gov/EID/content/13/5/761.htm