A Systematic Review of Reported Reassortant Viral Lineages of Influenza A

August 17, 2016 — 

Most previous evolutionary studies of influenza A have focussed on genetic drift, or reassortment of specific gene segments, hosts or subtypes. We conducted a systematic literature review to identify reported claimed reassortant influenza A lineages with genomic data available in GenBank, to obtain 646 unique first-report isolates out of a possible 20,781 open-access genomes.

RESULTS:
After adjusting for correlations, only: swine as host, China, Europe, Japan and years between 1997 and 2002; remained as significant risk factors for the reporting of reassortant viral lineages. For swine H1, more reassortants were observed in the North American H1 clade compared with the Eurasian avian-like H1N1 clade. Conversely, for avian H5 isolates, a higher number of reported reassortants were observed in the European H5N2/H3N2 clade compared with the H5N2 North American clade.

CONCLUSIONS:
Despite unavoidable biases (publication, database choice and upload propensity) these results synthesize a large majority of the current literature on novel reported influenza A reassortants and are a potentially useful prerequisite to inform further algorithmic studies.

Pinsent A, Fraser C, Ferguson NM, Riley S; A systematic review of reported reassortant viral lineages of influenza A; A Systematic Review of Reported Reassortant Viral Lineages of Influenza A; BMC Infect Dis. 2016 Jan 5;16:3. doi: 10.1186/s12879-015-1298-9. PMID: 26732146 PMCID: PMC4702296 Free PMC Article