Effect of the Route of Administration on the Mucosal and Systemic Immune Responses to Lawsonia Intracellularis Vaccine in Pigs

May 25, 2016 — 

In an on-farm study, 40 weaned piglets aged 3 weeks were vaccinated with Lawsonia intracellularis vaccine orally, IM or IP while a fourth group remained unvaccinated. All vaccinated animals showed increased serum levels of L. intracellularis-specific IgG antibodies, but significantly elevated concentrations of specific IgG, IgA and cytokines were generated in ileal mucosal secretions from the orally and IP vaccinated pigs when examined at 17 days after vaccination.
Nogueira MG, Collins AM, Dunlop RH, Emery D; Effect of the Route of Administration on the Mucosal and Systemic Immune Responses to Lawsonia Intracellularis Vaccine in Pigs; Aust Vet J. 2015 Apr;93(4):124-6. doi: 10.1111/avj.12305. PMID: 25817978