Prevention of porcine Clostridium difficile-associated disease by competitive exclusion with nontoxigenic organisms
November 7, 2007 — J. Glenn Songer, Randy Jones, Michael A. Anderson, Angelique J. Barbara, Karen W. Post and Hien T. Trinh
Clostridium difficile is widely known as a cause of disease in humans, and has emerged as an important problem in neonatal swine. No commercial product is available for immunoprophylaxis of C. difficile-associated disease, but success in preventing experimental infections in hamsters by use of nontoxigenic strains to competitively exclude toxigenic strains led us to try this method in neonatal pigs. Spores were administered orally to newborn pigs or were sprayed onto perineum and teats of dams. Significantly more piglets were weaned among litters receiving spores orally, and average weaning weights were significantly higher for both treatment groups than for controls. Toxins A and B were detected in 44.8% of litters and 16.5% of piglets born to sprayed sows and 58.3% of litters and 15.4% of piglets in the control group. However, toxins were detected in only 13.8% of litters and 3.4% of piglets given spores orally. These data support a contention that precolonization by a nontoxigenic strain can ameliorate the pre-weaning growth retardation associated with C. difficile infection in piglets.
J. Glenn Songer, Randy Jones, Michael A. Anderson, Angelique J. Barbara, Karen W. Post and Hien T. Trinh, Prevention of porcine Clostridium difficile-associated disease by competitive exclusion with nontoxigenic organisms, Veterinary Microbiology, Volume 124, Issues 3-4, 6 October 2007, Pages 358-361
- Next story: Upcoming Conference: North American Veterinary Conference
- Next in category: Lactation Intake and Creep Feed on Performance
- Previous in category: Why do pigs root and in what will they root? A review on the exploratory behaviour of pigs in relation to environmental enrichment
- Previous story: IPVS 2008 Announcement