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Cross Protective Immune Responses in Nursing Piglets Infected with a US Spike-Insertion Deletion Porcine Epidemic Diarrhea Virus Strain and Challenged with an Original US PEDV Strain

We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20-29 days post-inoculation (dpi), all pigs were challenged with the PC21A strain. The S-INDEL-inoculated pigs had lower ileal IgA antibody secreting cells, serum IgA and neutralizing antibody titers compared with PC21A-inoculated pigs. No pigs in the PC21A-group developed diarrhea, whereas 81 and 100% of pigs in the S-INDEL and mock-groups had diarrhea post challenge, respectively. S-INDEL induced partial protective immunity against the original US PEDV strain.

Annamalai T, Lin CM, Gao X, Liu X, Lu Z, Saif LJ, Wang Q; Cross Protective Immune Responses in Nursing Piglets Infected with a US Spike-Insertion Deletion Porcine Epidemic Diarrhea Virus Strain and Challenged with an Original US PEDV Strain; Vet Res. 2017 Oct 6;48(1):61. doi: 10.1186/s13567-017-0469-7. PMID: 28985754 DOI: 10.1186/s13567-017-0469-7 Click here to read the free full text.