Calves are Susceptible to Infection with the Newly Emerged Porcine Deltacoronavirus, but not with the Swine Enteric Alphacoronavirus, Porcine Epidemic Diarrhea Virus

August 9, 2017 — 

Fecal virus shedding, seroconversion and histopathology were evaluated in 3-7-year-old gnotobiotic calves orally inoculated with porcine deltacoronavirus (PDCoV) (9.0-9.6 log10 genomic equivalents [GE] of OH-FD22-P5; n=4) or porcine epidemic diarrhea virus (PEDV) (10.2-12.5 log10 GE of PC21A; n=3). In PDCoV-inoculated calves, an acute but persisting fecal viral RNA shedding and PDCoV-specific serum IgG antibody responses were observed, but without lesions or clinical disease. However, no fecal shedding, seroconversion, histological lesions, and clinical disease were detected in PEDV-inoculated calves. Our data indicate that calves are susceptible to infection by the newly emerged PDCoV, but not by the swine coronavirus, PEDV.

Jung, K., Hu, H. & Saif, L.; Calves are Susceptible to Infection with the Newly Emerged Porcine Deltacoronavirus, but not with the Swine Enteric Alphacoronavirus, Porcine Epidemic Diarrhea Virus ; Arch Virol (2017) 162: 2357. https://doi.org/10.1007/s00705-017-3351-z